Molecular mimicry in autoimmune pancreatitis: an interesting idea
نویسندگان
چکیده
منابع مشابه
Molecular mimicry in autoimmune disease.
The origins of autoimmune disease are multifactorial. Environmental factors and a genetic predisposition result in tissue injury caused by autoreactive T cells or antibodies. Usually a single organ or individual cell type is aVected in the absence of gross abnormalities of the immune system. Autoimmune diseases tend to have long, asymptomatic prodromal periods and the initiating events leading ...
متن کاملAutoimmune Pancreatitis: An Autoimmune or Immunoinflammatory Disease?
Autoimmune pancreatitis (AIP) has been widely presumed to be an autoimmune disease that is characterized by elevated IgG and/or IgG4, the presence of autoantibodies, and an infiltration of lymphocytes and plasma cells with fibrosis. However, no detailed immunological studies have been published. To define immunological changes in AIP in detail, and to review evidence for autoimmunity which may ...
متن کاملMolecular mimicry in the autoimmune pathogenesis of rheumatic heart disease.
Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with streptococcal M protein and cardiac myosin. Recent studies have unraveled the potent...
متن کامل[Molecular mimicry in the etiology of autoimmune diseases].
There are currently more than 80 different autoimmune diseases, affecting approximately 100 million people worldwide. The etiology of most autoimmune diseases is unknown. The highest incidence of these diseases is in the developed countries and they are more common in women than in men. Among the most often listed factors responsible for the onset of autoimmunity are genetic predisposition and...
متن کاملMolecular Mimicry and T Cell–mediated Autoimmune Disease
B oth T cell tolerance and productive T cell responses require the interaction of the TCR with specific MHC–peptide ligands, triggering a cascade of signals that ultimately can lead to either proliferation or cell death (1– 3). These two opposing processes, which can occur during both peripheral T cell activation and/or positive/negative selection of T cells in the thymus, seem to be tuned by t...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2005
ISSN: 1582-1838,1582-4934
DOI: 10.1111/j.1582-4934.2005.tb00507.x